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STAFF INFORMATION

DR ANDREW LAURIE Ph.D
Scientific Officer, Molecular Pathology
Phone : 03 3786001(internal 8600)
Fax : 03 364 0545
EMail : andrew.laurie@cdhb.govt.nz

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Andrew graduated B.Sc.(hons) from University of Canterbury in 1993, and completed a Ph.D. in bacterial genetics at University of Waikato in 1998. After two postdocs (Umea University, Sweden; and Landcare Research, Lincoln) he joined the Molecular Pathology group at CHLabs in 2003. Primary roles within the laboratory are: analysis of genetic determinants for hypercholesterolaemia (LDLR, ApoB), Gilbert’s disease, haemophilia A (F8) and other coagulation disorders (Von Willebrand disease, factor X deficiency, antithrombin deficiency). He co-ordinates the pre-implantation genetic diagnosis (PGD) service which is offered for a range of severe genetic disorders (cystic fibrosis, Huntington disease, Fragile X syndrome, haemophilia, osteogenesis imperfecta).

Publications

  1. LAURIE AD. ,George PM
    ",Evaluation of high-resolution melting analysis for screening the LDL receptor gene.
    Clin Biochem 2009;42(6):528-35
  2. Homer VM. ,Marais AD. ,Charlton F. ,LAURIE AD. ,Hurndell N. ,Scott R. ,Mangili F. ,George PM
    ",Identification and characterization of two non-secreted PCSK9 mutants associated with familial hypercholesterolemia in cohorts from New Zealand and South Africa.
    Atherosclerosis 2008;196(2):659-66
  3. LAURIE AD. ,Sheen C. ,Hanrahan V ,Smith MP ,George PM
    ",The molecular aetiology of haemophilia A in a New Zealand patient group.
    Haemophilia 2007;13(4):420-7
  4. LAURIE AD. ,Smith MP ,George PM
    ",Detection of Factor VIII Gene Mutations by High-Resolution Melting Analysis.
    Clin Chem. [Epub ahead of print] 2007;53(12):2211-4
  5. Punzalan RE. ,Sy RG. ,Santos RS. ,Cutiongco EM. ,Gosiengfiao S. ,Fadriguilan E. ,George PM ,LAURIE AD.
    ",Low density lipoprotein--receptor (LDL-R) gene mutations among Filipinos with familial hypercholesterolemia.
    J Atheroscler Thromb. 2005;12(5):276-83
  6. Llyod-Jones G. ,LAURIE AD. ,Tizzard AC.
    ",Quantification of the Pseudomonas population in New Zealand soils by fluorogenic PCR assay and culturing techniques.
    J Microbiol Methods. 2005;60(2):217-24
  7. Leusch FDL. ,Van Den Heuvel MR. ,LAURIE AD. ,Chapman HF. ,Ravi Gooneratne S. ,Tremblay LA.
    ",Quantification of vitellogenin mRNA induction in mosquitofish (Gambusia affinis) by reverse transcription real-time polymerase chain reaction (RT-PCR).
    Biomarkers. 2005;10(6):429-38
  8. LAURIE AD. ,Scott RS. ,George PM
    ",Genetic screening of patients with familial hypercholesterolaemia (FH): a New Zealand perspective
    Atheroscler Suppl. 2004;5(5):13-5
  9. LAURIE AD.
    "Quantitation of metallothionein mRNA from the New Zealand common bully (Gobiomorphus cotidianus) and its implications for biomonitoring."
    New Xealand Journal of Marine and Freshwater Research 2004;38:869-877
  10. LAURIE AD. ,Bernardo LM. ,Sze CC. ,Skarfstad E. ,Szalewska-Palasz A. ,Nystrom T. ,Shingler V.
    ",The role of the alarmone (p)ppGpp in sigma N competition for core RNA polymerase.
    J Biol Chem. 2003;278(3):1494-503
  11. Sze CC. ,LAURIE AD. ,Shingler V.
    ",In vivo and in vitro effects of integration host factor at the DmpR-regulated sigma(54)-dependent Po promoter. J Bacteriol. 2001 May; 183(9): 2842-51.
    J Bacteriol. 2001;183(9):2842-51
  12. LAURIE AD. ,Lloyn-Jones G.
    ",Quantification of phnAc and nahAc in contaminated new zealand soils by competitive PCR.
    Appl Environ Microbiol. 2000;66(5):1814-7
  13. Lloyd-Jones G. ,LAURIE AD. ,Hunter EWF. ,Fraser R.
    "Analysis of catabolic genes for naphthalene and phenanthrene degradation in contaminated New Zealand soils."
    FEMS Microbiology Ecology. 1999;29:69-79
  14. LAURIE AD. ,Lloyd-Jones G.
    ",The phn genes of Burkholderia sp. strain RP007 constitute a divergent gene cluster for polycyclic aromatic hydrocarbon catabolism.
    J Bacteriol. 1999;181(2):531-40
  15. LAURIE AD. ,Lloynd-Jones G.
    ",Conserved and hybrid meta-cleavage operons from PAH-degrading Burkholderia RP007.
    Biochem Biophys Res Commun. 1999;262(1):308-14
  16. Lloyd-Jones G. ,LAURIE AD. ,Hunter DWF.
    "Molecular ecology of the microbial degradation of aromatic compounds."
    Australasian Biotechnology. 1998;8:47-49
    Information last updated on 26 August 2009


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