Metoclopramide

Upper GI prokinetic plus weak central effects via dopamine receptors.
Indicated for GI gastroparesis and functional bowel obstruction (commonly caused by opioids) and for GORD.
10 mg TDS/QID PO or subcut (or IV 4-6 hourly).
Important to give A/C – 20-30 minutes before meals.
Contraindicated in complete proximal bowel obstruction and Parkinson's Disease.
Watch for agitation, particularly in higher doses and in young people (especially women).
The elderly are at increased risk of extrapyramidal side effects.

Note: Domperidone should be considered if metoclopramide use is contraindicated, e.g., Parkinson's Disease. It can only be used orally.


Information about this Canterbury DHB document (4085):
Document Owner:	Palliative Care Service (see Who's Who)
Issue Date:	July 2009
Next Review:	July 2010
Keywords:
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Topic Code: 4085